GUIDELINES

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1. INTRODUCTION
   1. BACKGROUND
   2. GENETIC COUNSELLING
2. STAFF
   1. DIRECTOR/MANAGER/LABORATORY SUPERVISOR
   2. DIAGNOSTIC WORK SUPERVISOR /SECTION HEAD
   3. TECHNICAL STAFF
   4. TRAINEE STAFF
   5. ANCILLARY STAFF
   6. ADMINISTRATIVE STAFF
   7. MEDICAL COLLABORATION
   8. SCIENTIFIC COLLABORATION
3. WORKLOAD RECOMMENDATIONS
4. LABORATORY PROCEDURES
   1. GENERAL
      1. REFERALS
      2. STANDARD OPERATIONAL PROCEDURES (SOPs)
   2. EQUIPMENT AND FACILITIES
      1. SAFETY CABINETS
      2. INCUBATORS
      3. IMAGE CAPTURE SYSTEMS
   3. TECHNICAL ASPECTS OF CYTOGENETICS
      1. CELL CULTURES
      2. BANDING
   4. ANALYSIS
      1. KARYOTYPING/CHROMOSOME ANALYSIS
      2. CHECKING
   5. INTRODUCTION OF NEW LABORATORY PROCEDURES
      1. USE OF MOLECULAR TECHNIQUES
5. SPECIFIC CHROMOSOMAL ANALYSIS
   1. PRENATAL
      1. AMINOCYTE CULTURES
      2. CHORIONIC VILLI CULTURES
      3. FOETAL BLOOD CULTURES
      4. MOSAICISM IN PRENATAL STUDIES
   2. POSTNATAL
      1. POSTNATAL CHROMOSOME ANALYSIS OF BLOOD AND SOLID TISSUE/PRODUCTS OF CONCEPTION
      2. MOSAICISM
      3. PRODUCTS OF CONCEPTION/FOLLOW UP SPECIMEN
      4. CHROMOSOME INSTABILITY SYNDROMES
      5. OTHER RARE SYNDROMES DETECTED BY CYTOGENETIC ANALYSIS
   3. ONCOLOGY: LEUKAEMIAS AND SOLID TUMOURS
      1. BONE MARROW
      2. SOLID TUMOUR
      3. HAEMATOLOGICAL CHROMOSOME ANALYSIS
      4. ONCOLOGY CHROMOSOME ANALYSIS
   4. CGH AND MICROARRAY TECHNOLOGY
6. FLUORESCENCE IN-SITU HYBRIDISATION (FISH)
   1. GENERAL
   2. EQUIPMENT, FACILITIES AND SAFETY
   3. REAGENTS
   4. TECHNIQUES
      1. WHOLE CHROMOSOME PAINTING
      2. DETECTION OF MICRODELETION AND SUBTELOMERIC REGION ANALYSIS
      3. INTERPHASE FISH
   5. ANALYSIS
      1. CONSTITUTIONAL
      2. HEAMATOLOGY AND ONCOLOGY
   6. CHECKING
7. QF-PCR FOR RAPID PRENATAL DIAGNOSIS OF ANEUPLOIDY
   1. EQUIPMENT, FACILITIES AND SAFETY
   2. SAMPLE PREPARATION
   3. ANALYSIS
   4. REPORTING
8. REPORTING
   1. STANDARDISATION
      1. SUBSTANDARD ANALYSIS
      2. CHROMOSOMAL VARIANTS
      3. MOSAICISM AND PSEUDOMOSAICISM
      4. MATERNAL CONTAMINATION
      5. FISH REPORTS
9. SUCCESS RATES
10. REPORTING TIME
    1. PROVISIONAL RESULTS
11. CLINICAL RECORDS AND STORAGE
    1. RECORDS
       1. RETENTION OF DOCUMENTATION
    2. SPECIMEN STORAGE
       1. STORAGE TIMES

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Last changed: 2008-02-05