Articles and reports released by unit 5

Workpackage 5.1: Validation of Diagnostic Tests

Publications

• Brdička R., Otáhalová E.1, Čamajová J., Štambergová A., Vraná M.: Klinická validace genetického testování, Klinickà biochemie a metabolismus 1/2007
• Brdička, R., Vraná, M., Otáhalová, E., Štambergová, A., Čamajová, J.: Analytická validace metod molekulární genetiky určených pro analýzu lidského genomu, Klinickà biochemie a metabolismus 1/2007

Poster Abstracts

• "Multiplex Ligation-dependent Probe Amplification (MLPA) - an interlaboratory collaborative validation study": T. Janssens, A. Corveleyn, F. Le Calvez, E. Dequeker and G. Matthijs. European Journal of Human Genetics, vol 15(1), June 2007.
• "Evaluation and introduction of new techniques in the genetic testing service by EuroGentest unit 5": N. van der Stoep, C.D.M. Paridon, M. Macek, G. Matthijs and B. Bakker. European Journal of Human Genetics, vol 15(1), June 2007.

Reports

• All documents related to the MLPA validation are lon the EUGT website: http://www.eurogentest.org/web/info/public/unit1/MLPAvalidation.xhtml

Workpackage 5.2: Inventory and Evaluation New Technologies

Publications

• Boon EM, Schlecht HB, Martin P, Daniels G, Vossen RH, den Dunnen JT, Bakker B, Elles R. Y chromosome detection by Real Time PCR and pyrophosphorolysis-activated polymerisation using free fetal DNA isolated from maternal plasma. Prenatal Diagnosis. 2007 Oct;27(10):932-7
• VAN ZIMMEREN E, VERBEURE B, MATTHIJS G, VAN OVERWALLE G. (2006) A clearing house for diagnostic testing: the solution to ensure access to and use of patented genetic inventions?, Bull World Health Organ. 84:352-359. Epub 2006 May 17.

Publications on the EUGT website

• Technology Database
• First results for the evaluation of HR-MCA : Overview on ongoing Evaluation of Melting Curve Analysis (MCA) by EuroGentest

Workpackage 5.3: IPR Issues

Full Publications

• VAN OVERWALLE G., VAN ZIMMEREN, E., VERBEURE, B. & MATTHIJS, G., ‘Dealing with Patent Fragmentation in ICT and Genetics: Patent Pools and Clearing Houses’, First Monday, May 2007 (http://firstmonday.org/)
• MATTHIJS G., ‘DNA diagnostics in practice’ in Gene Patents and Public Health, VAN OVERWALLE, G. (ed.), Brussel, Bruylant, 2007, 27-44
• VAN OVERWALLE G. (ed.), Gene Patents and Public Health, Brussel, Bruylant, 2007, 241 p.
• VAN OVERWALLE G., ‘Gene Patents and Public Health. Setting the Scene’, in Gene Patents and Public Health, VAN OVERWALLE, G. (ed.), Brussel, Bruylant, 2007, 11-24
• VAN OVERWALLE G., ‘The Belgian Compulsory License for Public Health’, in Gene Patents and Public Health, VAN OVERWALLE, G. (ed.), Brussel, Bruylant, 2007, 199-209
• VAN ZIMMEREN E. and REQUENA G.,‘Ex-officio licensing in the medical sector: the French model’ in Gene Patents and Public Health, VAN OVERWALLE, G. (ed.), Brussel, Bruylant, 2007, 123-147
• VAN OVERWALLE, G. ‘Patent Law in Crisis? Functions and Limits of the Patent System in a Globalised World’, Revue de la Faculté de Droit de l’Université de Liège 2007;317-322
• VAN OVERWALLE G., ‘Human Rights’ Limitations in Patent Law’, in GROSHEIDE, W. (ed.), The Human Rights Paradox in Intellectual Property Law, Oxford, Edwar Elgar Publishing Ltd, 2007 (in press)
• VAN OVERWALLE, G., ‘L’ intérêt général, le domaine public, les commons et le droit des brevets d’invention’, in L'intérêt général et l'accès à l'information en propriété intellectuelle, Brussel, Bruylant, 2007 (in press)
• VAN OVERWALLE G., ‘Biotechnology and Patents: Global Standards, European Approaches and National Accents’, in WÜGER, D., and COTTIER, T. (eds.), Genetic Engineering and the World Trade System, Cambridge University Press, 2007 (in press)
• VAN OVERWALLE G., ‘Recente ontwikkelingen in het octrooirecht’ in Recht in beweging, MAKLU, 2007, 131-151
• VAN OVERWALLE G., ‘Reshaping Bio-Patents: Measures to Restore Trust in the Patent System’, in SOMSEN, H. (ed.), The Regulatory Challenge of Biotechnology. Human Genetics, Food and Patents, Cheltenham, UK - Northhampton, US, Edward Elgar Ltd., 2007, 238-256
• VAN OVERWALLE G., VAN ZIMMEREN E., VERBEURE B., MATTHIJS, G., ‘Models for facilitating access to patents on genetic inventions’, 7 Nature Review Genetics, February 2006, 143-148.
• VAN ZIMMEREN E., VERBEURE B., MATTHIJS G., VAN OVERWALLE, G., ‘A Clearinghouse for Diagnostic Testing: the Solution to Ensure Access to and Use of Patented Genetic Inventions?’, Bulletin of the World Health Organization, 2006, 352-359.
• VERBEUR, B., MATTHIJS G., VAN OVERWALLE G., ‘Analysing DNA patents in relation with diagnostic genetic testing’, 14 European Journal of Human Genetics (EJHG), vol. 1, January 2006, 26-33.
• VERBEURE, B., VAN ZIMMEREN, E., MATTHIJS, G., VAN OVERWALLE, G., ‘Patent pools and diagnostic testing’, 24 Trends in Biotechnology (TIB), vol. 3, March 2006, 115-120.
• VAN OVERWALLE, G., VAN ZIMMEREN, E., VERBEURE, B., MATTHIJS, G., 'Models for facilitating access to patents on genetic inventions', Nature Genetic Reviews (2006) 7:143-148. doi:10.1038/nrg1765; published online 29 December 2005
• VERBEURE, B., MATTHIJS, G. & VAN OVERWALLE, G., 'Analysing DNA patents in relation with diagnostic genetic testing', European Journal of Human Genetics (EJHG), European Journal of Human Genetics (2006) 14, 26-33. doi:10.1038/sj.ejhg.5201503; published online 12 October 2005.

Workpackage 5.4: Databases and tools

Full Publications

• Devereau, A. and Walker, N. (2007). Poster 1285: Measuring the quality of computer tools used in diagnostic genetic testing. European Journal of Human Genetics, vol. 15 supplement 1, June 2007. European Human Genetics Conference, June 16-19 2007, Nice.
• Sjozef van Baal, Polynikis Kaimakis1, Manyphong Phommarinh, Daphne Koumbi, Harry Cuppens, Francesca Riccardino, Milan Macek Jr, Charles R. Scriver and George P. Patrinos: FINDbase: a relational database recording frequencies of genetic defects leading to inherited disorders worldwide, Published online 28 November 2006
• NGRL Manchester: Decision support for molecular diagnostic laboratories using Interactive Biosoftware Alamut v1.2